Title: Nanomaterials used for magnetic hyperthermia based cancer therapy applications Abstract: Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is one promising antitumoral nano therapy, owning to its power to generate heat under the application of alternating magnetic field. However, although the ultimate target of these treatments, the healing potential and its relation with
Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is one promising antitumoral nano therapy, owning to its power to generate heat under the application of alternating magnetic field. However, although the ultimate target of these treatments, the healing potential and its relation with the magnetic behavior of the employed magnetic nanomaterials are rarely studied. Here we provide to bridge between the heating potential and magnetic properties such as anisotropy energy constant and saturation magnetization of the nano-magnets by simultaneous investigation of both hyperthermia and magnetism in a controlled set of variables given by response surface methodology. In the study, we have simultaneously investigated the effect of various synthesis parameters like cation ratio, reaction temperature, and time on the magnetic response and heat generation of Manganese-doped ferrite nanomaterials synthesized by a simple hydrothermal route. The optimum generation of heat and magnetization is obtained at a cationic ratio of approximately 42 at a temperature of 100°C for a time period of 4 h. Besides the synthesis parameters, the effect of the application of a new age natural surfactant, Stevioside – a plant bioactive, was also assessed on the hyperthermic profile of ferrite nanomaterials. The optimized nanomaterials were then evaluated for in vitro magnetic hyperthermia application for cancer therapy against glioblastoma in terms of cell viability, effect on cellular cytoskeleton, and morphological alterations. Furthermore, the correlation between the magnetic properties of the synthesized nanomaterial with its hyperthermia output was also established using the K.V.Ms variable where K, V, and Ms are the anisotropy energy constant, volume, and saturation magnetization of the nanomaterial respectively. It was found that the intensity of heat generation decreases with an increase in K.V.Ms value, beyond 950 J.emu/g.
Dr.Deepika Sharma is Currently working as a Scientist C at the Institute of Nano Science and Technology (INST), Mohali (Department of Science and Technology, Government of India). My Lab research interest lies at the interface of engineering, medicine, and biology to develop novel platforms for understanding, diagnosing, and treating human disease. Specifically, our work is focused on diagnostics and treatments for cancer. The research work is centered on designing and developing of targeted nanoparticles to perform complex tasks such as multimodal, non-invasive tumor imaging; triggers the release of a targeted, therapeutic payload, hyperthermia, and multifunctional agents for cancer therapies. I am also a member of the Indian Association For Cancer Research (IACR), the Indian Association for Hyperthermic Oncology and Medicine (IAHOM) and the Biotech Research Society of India (BRSI).