Dr. Hussein J. Ahmed

University of Khartoum, Sudan

Title: Knowledge and Attitude of Sudanese Emergency Registrars Towards the use of Tissue Plasminogen Activator in the Management of Acute Ischemic Stroke



Background: Tissue plasminogen activator within 4.5 hours from onset improves outcome in patients with ischemic stroke and has been recommended by several international guidelines.

Objective: To assess the knowledge and attitude of Sudanese emergency Medicine Registrars towards the use of tissue plasminogen activator in the management of Acute Ischemic Stroke.

Methods: This is a descriptive, cross-sectional, hospital-based study. The study was conducted in emergency departments at Khartoum State Hospitals during the period from May to July 2021. The study sample was 150 emergencies medicine registrars fulfilled the inclusion criteria of the study. Data was collected by using self-administered questionnaire as a Google-form that was sent to the study participants by email.

Results: The overall knowledge of the participants about tissue plasminogen activators in management of acute ischemic stroke patients at emergency department was average 55(36.7%), poor 54(36%) and good 41(27.3%). On the other hand, no significant difference in total knowledge according to age, however it good and average level of knowledge significantly higher among females, level 3 and level 4 of training and years of experience 5 – 10 years (P value < 0.05). The overall attitude of the participants was positive 62(41.3%), neutral 45(30%) and negative 43(28.7%). On the other hand the positive attitude regarding tissue plasminogen activators for acute ischemic stroke patients was significantly associated with age 30 – 40 years, females, level 3 and 4 of training and experience 5 – 10 years (P value < 0.05).

Conclusion: The problems faced by the participants in use of tissue plasminogen activators were unavailability of stroke team in the hospitals, unavailability of protocol for care pathway of acute ischemic stroke management in the hospitals and no tissue plasminogen was offered.


Dr. Hussein J. Ahmed, presently working as tutor at department of Anatomy, and department of surgery, University of Khartoum, Faculty of medicine, Sudan.

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