Title: Role of Polyphenols in Neuronal Disorders through Calcium Homeostasis
Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5′-triphosphate (ATP)-induced calcium signaling using digital imaging methods for intracellular free Ca2+ concentration ([Ca 2+] I), reactive oxygen species (ROS) and mitochondrial membrane potential in PC12 cells and effects of C3G on glutamate-induced [Zn2+] I increase and cell death in cultured rat hippocampal neurons. As well as effect of Rotenone is an active compound of pesticide which is main cause of Parkinson’s disease in modern age. Effect of Solanum nigrum polyphenols on Parkinson’s disease rotenone induced. Parkinson’s model also will be discussed in this talk with recent outcomes. Reports suggest a possibility that cyanidin-3-glucoside can induce protection against agonist-induced neuronal cell death through inhibiting Ca2+ signals, Zinc concentration, oxidative stress, and mitochondrial depolarization.
Dr. Shazia Perveen presently working as Asst.Prof at Department of Zoology, The Women University Multan, Pakistan. She worked as Research Associate at National Institute for Biotechnology and Genetic Engineering Faisalabad, Pakistan. She received doctoral degree in the year 2015 from College of medicine, The Catholic University of Korea. Her research prime objective is analyzing the polyphenols effect on calcium channels and calcium homeostasis different cell lines and primary cell culture. To his credit, she has published 21 articles in various international peer reviewed journals.