Title: To Investigate the Synergistic and Sole Role of Different Antibiotics in ICV-STZ Induced Sporadic AD
Alzheimer’s disease is a chronic progressive neurodegenerative disease linked with the atrophy of the brain and death of brain cells. It is the second most common form of dementia that slowly affects memory, thinking, and other cognitive functions of the brain. Alzheimer’s is most common in old age people. There are a number of hypotheses suggesting initiation of AD such as deposition of abnormal proteins, decreased clearance of toxic proteins, and other metabolic disturbances. Scientists are currently working in search of developing newer therapeutics, newer techniques in view of early diagnosis and treatment of AD. The current research is focused on repurposing the drugs. Repurposing of drugs will be a cost-effective approach with known PK-PD properties of the drugs. New research suggests the use of antibiotics in various diseases associated with brain damage such as ALS, stroke, epilepsy, and dementia. Thus the present study was designed to evaluate the individual and synergistic effects of ceftriaxone and minocycline in ICV-STZ induced sporadic Alzheimer’s disease. We observed that the combination showed better effects in restoring memory and cognitive functions. The observation and analysis was based on biochemical, oxidative stress parameters, and neurochemical analysis.
Miss Shilpa Kumari is presently pursuing her Ph.D. in Pharmacy at Dept. of Pharm. Sci. & Tech., MRSPTU, Bathinda, Punjab, India. She had completed her M.Pharmacy in pharmacology from DoPST, MRSPTU, Bathinda, Punjab, India. Her research prime objective was to develop newer therapeutics for the management of sporadic Alzheimer’s disease. To her credit, she has published a review article in international peer reviewed journal. She has won best oral presentation and poster presentation awards at different conferences.