Title: Polymeric Nanoparticles
Polymeric nanomaterials are particles within the size range from 1 to 100 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticles” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. These materials have been used in a wide spectrum from health to the environment. Among these nanomaterials, polymeric nanomaterials play an important role for biotechnologically purposes. Polymeric nanoparticles (PNPs) are defined as particulate dispersions or solid particles of 10–100 nm in size. Within these PNPs, therapeutic agents (such as drugs, DNA, proteins, etc.) as well as fluorescent labels can be dissolved, entrapped, encapsulated or can be attached to the nanoparticle matrix. There are different advantages of PNP’s. First of all, easily incorporated into other activities related to drug delivery such as tissue engineering. Secondly, delivery of higher concentration of pharmaceutical agent to a desired location. Finally, improvement over traditional oral and intravenous methods of administration in terms of efficiency and effectiveness. The unique physical structure and the excellent chemical capacity are the most effective and the surprising characteristic of the PNP’s. There are different type of PNP’s such as polymeric nanoparticles, micelles, dendrimers, polymersome, polyplex, polymer-lipid hybrid, polymer/drug/conjugate systems. Preparation Techniques of PNPs, Surface Modifications of PNP’s and Moleculer Imprinted Polymers will explained in this speech. In addition to this, different applications such as Medical, Environmental health, and enzyme technologies will also explained.
Prof.Dr. Sinan Akgöl has established Biochemistry Research Group (BIOREGE) in 2010. Groups researches are heavily on development of specific adsorbents for purification of biomolecules from their natural environments. In recent years, isolation of biomolecules (protein, enzyme, antibody, nucleic acid, hormone etc.) from biological media has becoming an important issue in biotechnology, biochemistry, pharmacy and medical fields. Affinity technique is the foremost because of its high selectivity within the separation techniques. Dr. Akgöl and his group have developed monosize nano and microspheres, macrospheres, membranes and magnetic carriers and these carriers were modified to make them available protein purification, removal of toxic substance. Dr. Akgöl has investigated the usability of the polymeric nanosorbents developed by him in many applications such as bioseparation, sensor development, protein isolation/purification, etc.Currently, 9 PhD and 1 MSc students are working in the group. 12 MSc, 6 PhD theses have finished up to now. Over 100 scientific publications and 3 patent have produced by the group and 50 international presentations have been performed.