Title: Influence of Drugs and Vaccines on Mitochondria and Immune Neuroplasticity
Our accidental discoveries on experimental models of acute and chronic inflammatory diseases that were established in 1980’s resulted in multistep tumorigenesis and angiogenesis. Data include a series of first evidence for direct link between inflammation-induced time-course kinetics of developmental phases of immune dysfunction toward tissue growth and angiogenesis. Extension of these studies became relevant to recent definitions of acute inflammation, 2 highly regulated and biologically opposing arms, Yin (apoptosis, tumoricidal) and Yang (wound healing tumorigenic) properties of effective immunity. After birth, mitochondria, an important integral part of immune system is responsible for maintenance of health or initiation and progression of a wide range of immune disorders. Complex autonomic immune neuroplasticity (adaptive, horizontal, circadian rhythms, Power Within) is likely stretched-thin, weakened or destroyed by endogenous or exogenous forces (Geno toxins, frequent infections, current vaccines, drug abuse genetic mutations). A working roadmap into sympathetic-parasympathetic behaviors of immune dynamics suggests that in 20th century, nearly all classic disease categories (congenital, inheritance, neonatal, or induced) shifted to increase induced diseases in young and old in America, and secondarily altered genomic stability toward miss-matched expression and co-expression of pro-and anti-inflammatory mediators and immune dysfunction.
Conclusion: Chronic infections, drug abuse and current protocols for vaccination of pregnant women (unborn, fetus), newborn, infant or immune compromised individuals are likely to lead to hyper-, hypo-stimulation of immunity, exhaust mitochondrial bioenergetics and alter diverse histamine metabolism. Altered complex molecular dynamics of immune neuroplasticity are likely the causes, exacerbations or consequences of nearly all mild, moderate or severe immune disorders. Validity of century-old genomics (innate, perpendicular) as origins of ‘hereditary’ diseases (e.g., allergies, diabetes, neurological disorders or site-specific cancers) is also challenged. Ancestral/parental irreversible loss of immune neuroplasticity would secondarily destabilize chromosomal and genomic integrity and pre-genetic disposition of offspring. Deeper understanding of immunity helps develop universal safe vaccines for mimicking natural immunity and minimizing gene-environment-immune neuroplasticity for improving health and preventing diseases.
Selected Recent References:
Khatami M. In Inflammation, Aging and Cancer: Biological Injustices to Molecular Village that Guard Health. Berlin: Springer; 2017: 1-389. http://www.springer.com/gp/book/9783319664736
Khatami M. Immune Neuroplasticity (Power Within) is Weakened by Vaccines and Drugs (Power Without): Mitochondrial Sink Holes, Genomic Destabilization and Immune Disorders Hypothesis. Preprints 2021, 2021020499 (doi: 10.20944/preprints202102.0499.v1).
Khatami M: Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism). Clin Transl Med. 2018 Jul 2;7(1):20. doi: 10.1186/s40169-018-0193-6. PMID: 29961900; PMCID: PMC6026585.
Khatami M. Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint? Clin Transl Med. 2016;5:35. https://doi.org/10.1186/s40169-016-0108-
Khatami M (2020) Deceptology in cancer and vaccine sciences: Seeds of immune destruction, mini electric shocks in mitochondria- Alter neuroplasticity/electro biology of response profiles and increased diseases in 4 generations. A hypothesis. Clin Trans Med.
First published: 19 December 2020 https://doi.org/10.1002/ctm2.215
Khatami M. Inflammation, aging, and cancer: tumoricidal versus tumorigenesis of immunity: a common denominator mapping chronic diseases. Cell Biochem Biophys. 2009;55(2):55-79. doi: 10.1007/s12013-009-9059-2. Epub 2009 Aug 12. PMID: 19672563.
Khatami M. ‘Yin and Yang’ in inflammation: duality in innate immune cell function and tumorigenesis. Expert Opin Biol Ther. 2008 Oct;8(10):1461-72. doi: 10.1517/147125184.108.40.2061. PMID: 18774915.
Khatami M. Unresolved inflammation: ‘immune tsunami’ or erosion of integrity in immune-privileged and immune-responsive tissues and acute and chronic inflammatory diseases or cancer. Expert Opin Biol Ther. 2011 Nov;11(11):1419-32. doi: 10.1517/14712598.2011.592826. Epub 2011 Jun 11. PMID: 21663532.
Khatami M. Chronic Inflammation: Synergistic Interactions of Recruiting Macrophages (TAMs) and Eosinophils (Eos) with Host Mast Cells (MCs) and Tumorigenesis in CALTs. M-CSF, Suitable Biomarker for Cancer Diagnosis! Cancers (Basel). 2014 Jan 27;6(1):297-322. doi: 10.3390/cancers6010297. PMID: 24473090; PMCID: PMC3980605.
Mahin Khatami was Born in Tehran-Iran. She Immigrated to USA in 1969 After Training in Chemistry(BS) and Science Education(Ms). She Received Her MA in Biochemistry from Suny at Buffalo (1977) and PhD in Molecular Biology from The University of Pennsylvania (UPA, 1980). her Postdoctoral Trainings were in Physiology at The University of Virginia, Protein Chemistry(Proteomics) at the Fox Chase Cancer Institute and UPA. She was a Faculty of Medicine at The Department of Ophthalmology, Scheie Eye Institute, UPA, Until 1992. In Collaboration with A Team of Scientists, Under The Direction of John H. Rockey, MD, PhD, At UPA, She Quickly Earned her Supervisory Responsibilities on Two Major Projects; Cell and Molecular Biology of Diabetic Retinopathy/Maculopathy and Experimental Models of Acute and Chronic Ocular Inflammatory Diseases. In her Junior Academic Career, Dr. Khatami is Considered the Most Productive Scientist in USA as She Published 39 Scientific Articles and Over 60 Abstracts in Conference Proceedings in the First Decade of her Research. In 1998, at The National Cancer Institute (NCI), The National Institutes of Health (NIH), She was a Program Director and Health Scientist Administrator, involved in Developing Molecular Concepts for Utilization of Patient Bio Specimen for Large Clinical Trials Such as Prostate-Lung-Colorectal Ovarian (PLCO) Cancer Screening Trials.